Antimicrobial resistance (AMR) is one of the ten (10) most serious global public health threats facing humanity. It is undermining a century of progress in medicine, as infections that were previously treatable and curable with drugs are becoming (or at risk of becoming) incurable. AMR occurs when bacteria, viruses, fungi and parasites no longer respond to antimicrobial agents. As a result of drug resistance, antibiotics and other antimicrobial agents become ineffective, and infections become difficult or impossible to treat, increasing the risk of disease spread, severe illness, and death. While antimicrobials are the backbone of modern medicine, their misuse and overuse in humans, animals, and plants is driving the emergence and spread of AMR. When antimicrobials enter soil and waterways, resistant strains of microbes can emerge in the environment, which can in turn infect animals and humans that come into contact with them. Bacterial resistance to antibiotics directly caused 1.27 million deaths and indirectly caused, contributed to, or was associated with an additional 4.95 million deaths annually in 2019. Over 450 000 people were affected by drug-resistant forms of tuberculosis (TB) in 2021. The emergence of extensively drug-resistant gonorrhea is another major public health concern. According to a World Bank report in 2017, if no action is taken now, AMR is likely to cause additional health expenditure of US$ 1.2 trillion per year by 2050 and push up to 24 million additional people (particularly in low-income countries) into extreme poverty by 2030. AMR can directly affect progress in achieving at least 6 of the 17 United Nations Sustainable Development Goals and can also be linked indirectly to the remaining 11. With this backdrop, the African Methods Episcopal University Millennium Fellows have designed this project as a means to increase knowledge on AMR and promote IPC and WASH through a One Health approach. During this project, a pre- and post-survey will be conducted on the targeted audience, which includes both students and community dwellers, thus aiming at fostering a responsible use of AMR.